Primary aims of this study were to (1) examine the direct, local effect of the GLP-1 analogues, exenatide and liraglutide, on microvascular function; and (2) assess whether the microvascular effects of exenatide and liraglutide differ in lean and obese individuals and in individuals with type 2 diabetes. This evidence concerns the gene GCG and type 2 diabetes mellitus.