The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) and the Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) outcome trials demonstrated that GLP-1 analogues, compared with placebo, increased time to cardiovascular event in individuals with type 2 diabetes [2, 3]. Here, GLP1R is linked to type 2 diabetes mellitus.