In contrast, Smits et al [8] observed no changes in capillary perfusion with either acute or short-term treatment with GLP-1 analogues in individuals with relatively well-controlled diabetes (HbA1c mean ± SEM: 7.3 ± 0.3% [mean: 56.3 mmol/mol]; age: 62.8 ± 6.9 years). This evidence concerns the gene GCG and diabetes mellitus.