In ovarian cancer, the tumor microenvironment is consist of immune cells, fibroblasts, extracellular matrix (ECM), some enzymes such as matrix metalloproteinase (MMPs), and growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor- β (TGF-β), and platelet-derived growth factor (PDGF). This evidence concerns the gene TGFB1 and ovarian cancer.