The transfer of mutated ataxin-3 into the nucleus could also be related to altered levels of Trim28 (log2 FC 0.94 in the cerebellum, log2 FC 1.59 in the cerebral cortex), which was shown to drive the nuclear accumulation of two distinct proteins: α-Syn and Tau implicated in Parkinson disease and Alzheimer disease, respectively [68]. The gene discussed is TRIM28; the disease is early-onset autosomal dominant Alzheimer disease.