HDAC3 and cancer: HDAC3 is key to neuronal survival, control of apoptosis, and is linked to neural disease,161 and memory function.162 HDAC3, together with HDAC1 and HDAC2, has been linked to cortical cell differentiation.154 HDAC8 is not found to be expressed in normal cells from the central or peripheral nervous system, but is linked to related cancers, notably childhood neuroblastoma, so could be a promising target in this field.26,163