HUWE1 and Familial prostate cancer: Histopathological analyses showed that HectH9 is overexpressed and that its overexpression is significantly correlated with numerous adverse clinicopathological factors, including increments of tumor stage and poor differentiation of prostate cancer (Fig. 7e, Supplementary Fig. 6c, d and Table 1), supporting the genetic results in TCGA database (Fig. 1a).