ATM and cancer: In this meta-analysis, we have four findings as follows: (i) ATM rs189037 significantly increased the overall risk of cancer under most of genetic models; (ii) the risky role of ATM rs189037 was prominent in non-smokers, but not observed in smokers; (iii) results focusing on LC were consistent with results of overall cancer; and (iv) GA genotype carriers of ATM rs189037 appeared not to suffer more cancer risk than GG wild-type carriers, no matter in smokers or in non-smokers.