Among these factors, five are known for their roles in the interaction with cancer cell such as interleukine-6 (IL-6) and IL-8, ten for angiogenesis regulation such as CXC-chemokine ligand-1 (CXCL-1), angiogenin and vascular endothelial growth factor-A (VEGF-A), two for matrix remodeling including TIMP-1 and TIMP-2, and fifteen for immune cell recruitment and activation such as macrophage colony-stimulating factor (M-CSF) and granulocyte M-CSF (GM-CSF) (Fig. 6-a). Here, TIMP2 is linked to cancer.