Compared to mock-treated mice, the severity of hepatic fibrosis in Sj-infected mice for 6 and 8 weeks with CTM treatment was obviously alleviated as shown by Sirius red staining (Fig. 4a) and ColI Western blotting analysis (Fig. 4b) (t-test: WT wk 6 vs CTM wk 6: t(175) = 6.85, P < 0.0001; WT wk 8 vs CTM wk 8: t(213) = 3.661, P = 0.0003). Here, HSF4 is linked to Hepatic fibrosis.