Likewise, preDSC lines expressed the multipotentiality markers OCT-4, NANOG, and ABCG2, their clonogenic efficiency ranged between 4 and 15% (Fig. 1), they remained alive for weeks in xenogeneic transplants (Fig. 4), and they had a therapeutic effect in an immune-based murine model of spontaneous abortion (Fig. 3). Here, POU5F1 is linked to spontaneous abortion.