Of the top hypermethylated probes in Table 2, eight probes were associated with decreased gene expression in CRC, corresponding to SV2B, MLH1/EPM2AIP1, C16orf62, RCOR3, BAIAP3, OGDHL, HDHD3 and ATP1B2. The complete list of all differentially expressed genes is given in Additional file 5: Supplementary Table 4. Here, SV2B is linked to colorectal carcinoma.