HLA-C and neoplasm: The mechanisms by which cancer cells evade the immune system should be thoroughly considered, and to include the evaluation of the functional status of the cancer cells, their proliferative and metastatic mechanisms, their metabolic status, the MHC expression which is responsible for displaying the tumor-derived antigen peptides on the antigen-presenting cells (APCs), and the mutanome that transforms mutated tumoral proteins into neoantigens, leading to immunome [22–24].