CD19 and B-cell chronic lymphocytic leukemia: Using the CAR-T lymphocytes as a therapeutic strategy has been associated with clinical success in hematological malignancies including acute myeloid leukemias by using chimeric CD123 [the IL3-Rα chain] receptor-modified T-lymphocytes [52], chronic lymphocytic leukemia (CLL) [53], pre-B acute lymphoblastic leukemia with CD19, and other lymphoid malignancies [54].