In response to schistosomal antigens, such as IPSE/α-1, a major secretory glycoprotein antigen from eggs of Schistosome, the notable upregulation of Th2 cytokines was detected, IL-4 and IL-10 [104] in particular, suggesting that in the Treg-mediated anti-inflammatory response, IL-4 and IL-10 might predominate in inhibiting the Th1-type response in malaria [94, 105], and IL-4 could suppress the IFN-γ-secreting Treg cells. This evidence concerns the gene IL4 and malaria.