KRAS and non-small cell lung carcinoma: We confirmed that only p65BTK, and not p77BTK, was expressed in NSCLC (Additional file 5: Table S2) and we showed that p65BTK over-expression correlated with mutations in KRAS or the RAS/MAPK pathway both in in vitro and in vivo models of lung cancers with mutated KRAS (Fig. 2).