Strikingly enough we found that the expression of miRNA30, miRNA203, miRNA128, miRNA148, miRNA183 and miRNA182 (targeting SNAI1 and SNAI2), miRNA16, miRNA200, miRNA141, miRNA203, miRNA205 and miRNA183 (targeting ZEB1 and ZEB2), miRNA17, miRNA16, miRNA378, miRNA1287 and miRNA 615 (targeting vimentin) and miRNA615, miRNA27 and miRNA194 (targeting CDH2) was upregulated while this of miRNA138 and miRNA199 (targeting CDH1) was downregulated in BRCA1-KO fibroblasts after exposure to cancer EVs (Fig. 8 and Additional file 1: Table S5). This evidence concerns the gene BRCA1 and cancer.