BRCA1 and cancer: Although we did not give definite confirmation that this cancer genetic material is responsible for the transformation of fibroblasts into colon cancer cells, it must be conceded that, according to conventional knowledge, phenotypes are determined by genotypes and therefore the dramatic modifications that lead a benign mesenchymal cell to turn into a malignant epithelial cell must be necessarily driven by critical genomic changes that are undoubtedly observed in the BRCA1-KO fibroblasts after exposure to colon cancer EVs.