qPCR analyses revealed that the mesenchymal markers (i.e. SNAI1, SNAI2, ZEB1, ZEB2, CDH2, vimentin and fibronectin) expression was decreased in cancer EVs-exposed BRCA1-KO fibroblasts, while the expression of CDH1 was increased (Fig. 6a). The gene discussed is BRCA1; the disease is cancer.