Since we had observed that xenotransplants obtained with cancer EVs-treated BRCA1-KO fibroblasts displayed colorectal cancer epithelial phenotype, as they were positive for CEA, CDX2, CK20 and CDH1, and negative for CK7 and vimentin (Fig. 2), we used this documented event as a readout for the accuracy of our microarray data mining. Here, BRCA1 is linked to cancer.