In order to test whether exosomes secreted from NSC can protect from Aβo-induced memory impairment, wild type mice were injected ICV with NSC-exo, MN-exo or PBS 24 h prior to receiving ICV injections of Aβo (3 μL of a 95 μM stock) or PBS (3 μl). This evidence concerns the gene ABO and memory impairment.