MTHFR and hyperhomocysteinemia: The 5–10-methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C and methionine synthase reductase (MTRR) A66G gene, may contribute to the risk of the development of hyperhomocysteinemia and are now believed to be good candidate for susceptibility to dyslipidemia and insulin resistance [9, 10].