Considering CHB patients as a control, area under ROC curve (AUROC) of HA, MIP-1β and CCL5 demonstrated that all three factors were reliable in distinguishing cirrhosis from CHB patients, the serum CCL5 level (AUC 0.8011, 95% confidence interval 0.690–0.913, P-value < 0.0001) was the most accurate indicator, and HA (AUC 0.752, 95% confidence interval 0.611–0.893, P-value 0.004) and MIP-1β (AUC 0.706, 95% confidence interval 0.571–0.841, P-value 0.0143) were also used to assess cirrhosis from CHB patients (Fig. 4). The gene discussed is CCL4; the disease is Cirrhosis.