REN and heart failure: In the context of non-ARVD patients with hypertension and diastolic dysfunction without a clinical diagnosis of heart failure, angiotensin-receptor blockers have been shown to reduce left ventricular mass and function and improve exercise tolerance; the changes in RWT observed in this study did not mirror this [28–30], but renin-angiotensin blockade has been shown to be associated with improved clinical outcomes in observational studies carried out in patients with ARVD [31, 32].