In their study, diabetic VDR-knockout mice developed more severe albuminuria and glomerulosclerosis due to increased glomerular basement membrane thickening and podocyte effacement; the Authors also found a correlation between lack of VDR and increased values of renin, angiotensinogen, transforming growth factor-β and connective tissue growth factor. The gene discussed is VDR; the disease is glomerulosclerosis.