Taking into account confounding factors similar to this publication using the long SF-36 questionnaire and available in our study (sex, age, education years, depression severity, STAI state, and CRP) in a linear regression model, the relationship between high S-ASM activity and impaired physical health remained nominally significant in the groups of unmedicated patients (p = 0.020) and healthy controls (p = 0.037) and was not present in medicated depressive patients and in remitted patients. Here, CRP is linked to major depressive disorder.