GRN and leukemia: However, in follow-up studies on this experiment and Eμ-TCL1 transplantations to other knockout mouse lines, we could recently provide evidence arguing that the observation of non-engraftment in Grn−/− mice was most likely caused by a CD8+ T cell-mediated immune response of Grn−/− mice against Grn expressing Eμ-TCL1 leukemia cells [89].