GRN and B-cell chronic lymphocytic leukemia: GRN serum levels were found statistically significantly elevated in CLL patients (median 605.60 ng/mL, range 1.51 ng/mL–8.07 μg/mL) compared to healthy controls (median 25.81 ng/mL, range 2.39 ng/Ml–60.84 ng/mL) (Figure 1a).