In the univariate analysis from 2004 to 2013 before excluding participants with chronic viral hepatitis (4573 HCC cases), HCC patients were more likely to use insulin glargine and insulin detemir, beta-blockers, and diuretics; and to have comorbid liver cirrhosis, chronic hepatitis B, chronic hepatitis C, heart failure, chronic kidney disease, and a higher Charlson index (Table S2). This evidence concerns the gene INS and heart failure.