One of the first examples is the discovery that about 5% of T cell acute lymphoblastic leukemia cases harbor small DNA insertions that create novel binding sites for recruitment of myeloblastosis (MYB) transcription factors and of the histone acetyltransferase CBP upstream of the T-cell acute lymphocytic leukemia protein 1 (TAL1) oncogene, thus creating a strong tumor-driving super-enhancer [71]. This evidence concerns the gene TAL1 and T-cell acute lymphoblastic leukemia.