Gene fusions involving E26 transformation-specific (ETS) family members and coding mutations mainly affecting speckle-type POZ protein (SPOP), forkhead box protein A1 (FOXA1), and isocitrate dehydrogenase 1 (IDH1) are found in primary prostate cancer [2,3,4,5,8,9]. The gene discussed is SPOP; the disease is prostate carcinoma.