RHOB and non-small cell lung carcinoma: We systematically profiled gene expression in normal (NHBE), immortalized (BEAS-2B) and fully transformed (NNK-BEAS-2B) human bronchial epithelial cells, as well as a NSCLC cell line (H157) from a smoker, and found that RhoB mRNA was decreased from immortalization stage [101], suggesting RhoB loss is an early event during lung tumorigenesis.