RHOB and neoplasm: Using high-throughput sequencing to detect miRNA, they determined that treatment with these agents caused a decrease in expression of miR-19a by downregulating SP-1, a transcription factor for miR-19a, which causes a decline in RHOB; therefore, chemotherapeutic agents that can cause a decrease in miR-19a expression, such as gemcitabine, may actually inhibit tumor progression by means of RHOB restoration [83,84,85,111].