Qi et al. [34] and Liu et al. [79] reported that treatment with resveratrol (3, 5, 4′-trihydroxystilbene), a stilbenoid endowed with anti-aging, anti-inflammatory, antioxidant, and anti-apoptotic activities [35,80,81], improved cognitive and behavioral functions in mice with AD induced by intracerebroventricular injection of Aβ1-42 as well as in animals with ovariectomy-induced anxiety- and depression-like behaviors, by inhibiting the NF-κB/NLRP3 signaling. Here, NLRP3 is linked to major depressive disorder.