CASP1 and Parkinson disease: Gordon et al. [6] observed an increase in IL-1β, caspase-1, NLRP3, and ASC expression in substantia nigra from PD mice induced by intranigral injection of 6-hydroxydopamine or α-syn preformed fibril, and that the pharmacological inhibition of inflammasome with MCC950, a recognized selective NLRP3 inhibitor, counteracted microglia activation, nigrostriatal degeneration, α-syn accumulation, and motor deficits in PD animals.