In addition, recent papers showed that RA patients are characterized by an increased mRNA and protein expression of inflammasome components, including NLRP3, ASC, caspase-1, and IL-1β levels in the synovia as well as circulating monocytes/macrophages, dendritic cells, and neutrophils, thus suggesting that the activation of NLRP3 inflammasome contributes both to tissues and systemic inflammation in RA [108,109,110,111,112]. Here, CASP1 is linked to rheumatoid arthritis.