Indeed, an overactivation of NLRP3 inflammasome signaling has been observed in the brain and blood of patients with neurological disorders, adipose tissue macrophages from obese and diabetic patients, as well as patients with rheumatoid arthritis (RA) and inflammatory bowel diseases (IBDs) [2,6,7,8,9]. The gene discussed is NLRP3; the disease is inflammatory bowel disease.