NLRP3 and diabetic kidney disease: In the second paper, Tao et al. [29] observed that the dihydroflavone dihydroquercetin exerted protective effects in rats with HFD/streptozotocin-induced diabetic nephropathy, by attenuating urine microalbumin excretion and renal histopathological lesions, through NLRP3 blockade via both inhibition of upstream NLRP3 signaling and acting directly on NLRP3 assembly.