TNF and colitis: Guo et al. [44] observed that oral administration of asiatic acid, a natural triterpenoid compound, dose-dependently attenuated body weight loss, histological damage, myeloperoxidase activity, as well as colonic TNF, IL-1β, IL-6, and IFN- γ levels in mice with DSS-induced colitis through the inhibition of NLRP3 inflammasome activation.