CASP1 and Alzheimer disease: Likewise, Liu et al. [30] observed that in vivo treatment of TgCRND8 mice (a transgenic model of AD) with Ginkgo biloba extracts improved cognitive functions, attenuated the loss of synaptic structural proteins, counteracted microglial activation, and decreased CNS neuroinflammation, through a direct blockade of caspase-1 activation.