NLRP3 and arthritic joint disease: Yang et al. [50] observed that oral administration of quercetin attenuated arthritic scores and paw edema decreased the joint levels of TNF, IL-6, PGE2, COX-2, iNOS, and Th17 cells and increased the number of Treg cells in mice with collagen-induced arthritis, through the inhibition of NLRP3 inflammasome activation.