NLRP3 and Parkinson disease: A pioneering study by Fan et al. [25] showed that tenuigenin, a natural extract from Polygala tenuifolia root, endowed with antioxidant, anti-aging, and anti-inflammatory properties, and able to cross the blood brain barrier (BBB), exerted beneficial effects in animals with MPTP-induced PD, through inhibition of NLRP3 activation and consequent decrease in IL-1β release [25].