NLRP3 and myeloid sarcoma: Likewise, Yamamoto et al. [78] observed that in vivo treatment with cyclic phosphatidic acid (2ccPA), a natural phospholipid, counteracted demyelination, microglial activation, and motor dysfunctions in mice with cuprizone-induced MS, through NLRP3 inhibition via suppression of mitochondrial oxidative stress and apoptotic pathways.