Likewise, Zhang et al. [72] showed that mice subjected to chronic mild stress (a model of depression) displayed an increase in IL-1β, caspase-1, NLRP3, and ASC in hippocampus tissues, and that the pharmacological blockade of NLRP3 attenuated central and peripheral inflammation and ameliorated depressive-like symptoms. The gene discussed is NLRP3; the disease is depressive disorder.