These authors observed that baicalin (5, 6-dihydroxy-7-O-glucuronide flavonoid glycoside), a major polyphenol compound extracted from Scutellaria radix roots, and salvianolic acid B, a natural compound extracted from Salvia miltiorrhiza, counteracted depressive-like behaviors and central neurogenic/inflammatory responses in rats with chronic unpredictable mild stress (CUMS) and LPS-induced depression, respectively, via direct blockade of NLRP3 inflammasome assembly. The gene discussed is NLRP3; the disease is major depressive disorder.