Zhang et al. [33] showed that crocin, a carotenoid isolated from Gardenia jasminoides and Crocus sativus, counteracted CNS neuroinflammation, locomotor disability, and immobility time, in concomitance with a shift of M1 pro-inflammatory microglia towards M2 anti-inflammatory phenotype, in mice with LPS-induced depression, through the inhibition of NLRP3 transcription step. The gene discussed is NLRP3; the disease is major depressive disorder.