MYH7 and congestive heart failure: MYH7 encoding the β-myosin heavy chain and MYBPC3 encoding cardiac myosin-binding protein C are the most common genes harboring causative mutations.[4–6] HCM is a frequent cause of sudden cardiac death (SCD) in youth and a significant underlying pathology for cardiac morbidity and mortality in adults.[5] It is believed that myocardial fibrosis, a hallmark of HCM, contributes to the development of SCD, ventricular tachyarrhythmias, and congestive heart failure (CHF).[7–11]