Frequent uniparental disomy resulting in loss of WT Kras and duplication of KrasG12D in 14 of 17 IM-induced T-ALLs is consistent with recent work demonstrating that KRAS mutations in acute myeloid leukemia and colorectal cancer frequently exhibit allelic imbalance that modulate competitive fitness and MEK dependency [30]. This evidence concerns the gene KRAS and colorectal cancer.