Once again, mice homozygous for the CD101 KO Idd10 region had a higher frequency of diabetes than those having two doses of the intact B6-derived Idd10 region (Fig 3B); however, the difference in diabetes occurrence was less significant between the homozygous genotypes derived from heterozygous breeders than when the mice had been bred from homozygous parents (Fig 3A). The gene discussed is CD101; the disease is diabetes mellitus.