To further characterize the role of the B6 Cd101 allele on myeloid cells for the protection from T1D, we generated NOD.B6 Idd10 scid mice and assessed T1D incidence in these recipients as compared to NOD scid recipients upon T cell transfer from CD101+/+ NOD.B6 Idd10 and CD101−/− NOD.B6 Idd10 donors. Here, CD101 is linked to type 1 diabetes mellitus.