CREBBP and small cell lung carcinoma: Furthermore, we analyzed the basic characteristics of Notch, CREBBP, and EP300 gene alterations in Chinese SCLC patients as all three genes have been identified as recurrent mutations in SCLC and may be related to therapy effects.11, 27 We found that the mutation frequencies of Notch, CREBBP, and EP300 were much lower than those of the reported previously.