The positive effects of vitamin K containing cream on anti‐EGFR drug‐related acneiform skin rash are based on an EGFR (re)activation on keratinocytes counteracting the EGFR inhibitory effects caused by the systemic anti‐EGFR treatment.11 We previously demonstrated a comparable anti‐tumor effect of anti‐cancer medication in both treatment arms. This evidence concerns the gene EGFR and neoplasm.