Tumor genome sequencing has resulted in the identification of somatic NF1 mutations in various non‐NF1–associated sporadic cancers, including melanoma,3, 4 lung cancer,5 glioblastoma,6 ovarian cancer,7 breast cancer, and acute myeloid leukemia.8 More than 1500 mutations in the NF1 gene have been reported in the Human Gene Mutation Database (HGMD), most of which are obvious loss­of­function alleles. Here, NF1 is linked to neoplasm.