A total of 1229 genes (640 up‐regulated and 589 down‐regulated) were obtained for PD, and nine DEGs (PTGDS,GPX3,SLC25A20,CACNA1D,LRRN3,POLR1D,ARHGAP26,TNFSF14 and VPS11) were selected as optimal PD biomarkers with great diagnostic value. The gene discussed is ARHGAP26; the disease is Parkinson disease.