APOE and Alzheimer disease: The PRS approach has also been applied to biological pathways related to AD but was not more predictive than APOE alone.17 The implementation of polygenic hazard score (PHS; closely related to PRS18) analysis in the ADNI data showed that PHS is associated with AD biomarkers (CSF and PET) in individuals without AD,19 and that higher PHS was associated with greater rates of cognitive and clinical decline, even after controlling for APOE status20; however, its predictive value was not quantified.