Although we had confirmed HBV replication and expression in stomach cancer and pancreatic cancer, the immunohistochemistry results suggested that HBX protein and anti-HBc protein were expressed only in the cytoplasm but not the nucleolus; the low rate of detectable cccDNA also indicated that HBV may inactively replicate in nonliver tissues. This evidence concerns the gene KRT88P and familial pancreatic carcinoma.