Whereas Nilsson et al. (9) found a lower risk of recurrence in 5-fluorouracil-treated colorectal cancer patients with a methylated versus unmethylated MGMT promoter, Shima et al. (3) concluded that neither MGMT promoter methylation nor loss of MGMT expression is a useful prognostic biomarker. The gene discussed is MGMT; the disease is colorectal cancer.