SIRT1 and familial dilated cardiomyopathy: As illustrated in Figure 6, the main mechanism leading to these favorable results may be related to MH activation of the AMPK function, which in turn activates AMPK/Sirt1 pathways and ameliorates the T2D‐induced lipid metabolism abnormalities; (c) the protective effect against DCM remained 3 months after MH withdrawal.