LncRNA SMARCC2 functions as a competing endogenous RNA (ceRNA) to inversely regulate miR‐551b‐3p abundance in gastric cancer.13 Furthermore, hypermethylation may be implicated in repressed expression of miR‐551b in breast cancer.15 Thus, it is worth to further investigate whether lncRNA or hypermethylation contributes to down‐regulation of miR‐551b‐3p expression in CCA. This evidence concerns the gene SMARCC2 and cholangiocarcinoma.