In line with the previous report indicating that loss of EGFR protein but not its tyrosine kinase activity sensitized cancer cells to chemotherapeutic agent (Weihua et al., 2008), EGFR tyrosine kinase inhibitors did not produce therapeutic effects for certain cancers (Cohen et al., 2003; Dancey and Freidlin, 2003; Fukuoka et al., 2003). This evidence concerns the gene EGFR and cancer.