MMP8 and tuberculosis: In a recent study, p38 MAPK signalling was involved in IL‐17‐driven MMP‐3 upregulation in Mtb infection.96 AMPK also regulates neutrophil‐derived MMP‐8 secretion in TB.101 Besides these pathways, Moores et al investigated the role of histone acetylation changes in Mtb‐induced MMP secretion.102 Silencing of HDAC1 by using siRNA resulted in downregulation of MMP‐3 expression, but this silencing had no effect on MMP‐1, which shows epigenetic modification of histone acetylation also plays a role in expression of MMP‐3.