Host‐directed therapy with MMP inhibitors has been investigated in several inflammatory conditions such as multiple sclerosis.156 Encouraging results have been obtained in experimental models of meningococcal and pneumococcal meningitis, where MMP inhibition resulted in decreased morbidity and mortality.157, 158 Similarly, Oehlers et al showed that vascular endothelial growth factor (VEGF) inhibitors in combination with rifampin reduce Mmarinum burden in zebrafish.159. Here, VEGFA is linked to pneumococcal meningitis.