But, unfortunately, mouse model of TB fails to develop the well‐characterized granuloma structure and cavitation which is commonly seen in human TB.7, 126 Moreover, mice do not express human MMP‐1 orthologue which, along with other MMPs, causes tissue destruction and transmission in disseminated human granuloma.34 As MMP‐1 is considered as dominant collagenase driving matrix destruction, therefore, the C57BL6 mouse model of TB has limited use to dissect the role of MMPs in Mtb‐driven immunopathology. Here, MMP1 is linked to Granuloma.