CXCL16 and acute respiratory distress syndrome: p38 mitogen‐activated protein kinases play critical roles in mediating cellular responses to stressors, and evidence has suggested that p38 is involved in the development of different stimuli‐induced ALI/ARDS.23, 24, 25 Nuclear factor‐kappa B (NF‐κB), a critical transcription factor that regulates the expression of various cytokines and chemokines, plays an important role in ALI.26 However, it remains unclear whether p38 and NF‐κB are associated with CXCL16/CXCR6 during ALI progression.