CircRNA ciRS‐7 was reported to be obviously increased in GC and led to a more aggressive oncogenic phenotype by antagonising the miR‐7‐mediated PTEN‐PI3K/AKT pathway.22 The circHIPK3 was revealed to exert a negative regulatory effect on miR‐124/miR‐29b expression and related to Ming′s classification and T stage in GC.23 Besides, circular RNA_LARP4 was suggested to restrain cell proliferation and invasion in GC.4 Similarly, we found that the circ‐SERPINE2 expression level was high in GC and improved tumour progress by sponging miR‐375 and regulating YWHAZ expression. This evidence concerns the gene AKT1 and neoplasm.