YWHAZ, also known as 14‐3‐3 zeta, belongs to one member of 14‐3‐3 protein family, which is highly conservative in all eukaryotes and can regulate many cell events, such as signal transduction, cell cycle and apoptosis.15 Recently, YWHAZ has been identified as a clinical prognostic indicator for some tumours.16 The study of Bergamaschi et al17 showed that 14‐3‐3 zeta was a key predictor for risk of failure in endocrine therapy and was valuable in recovering endocrine sensitivity and decreasing recurrence risk in breast cancer. This evidence concerns the gene YWHAZ and breast cancer.