The CSF NFL concentration in the MS and CIS diagnosis groups was significantly higher in the subgroup of patients who had a expanded Kurtzke Disability Status Scale (EDSS) score of 2.5 or higher (median 1208.5 ng·L−1) 6 months after lumbar puncture versus the subgroup of patients with EDSS scores of 0 to 2 (median 488 ng·L−1; P = 0.0269; Table 7). Here, NEFL is linked to in situ carcinoma.