In addition, characteristic patterns of elevation in serum immunoglobulins are observed in specific liver diseases such as raised immunoglobulin G (IgG) in autoimmune hepatitis, raised immunoglobulin A (IgA) in alcoholic liver disease, and raised immunoglobulin M (IgM) in primary biliary cholangitis (PBC), which can be applied to aid diagnosis in clinical practice [7–10]. This evidence concerns the gene CD40LG and liver disorder.