Moreover, since the gene encoding the amyloid precursor protein (APP) is located on the chromosome 21, trisomy induces an increase in the concentration of brain β-amyloid, and adult DS individuals of more than 40 years of age display early-onset Alzheimer-like neuropathology that additionally complicates their quality of life and independence possibilities [67, 68]. The gene discussed is APP; the disease is Dravet syndrome.