In the meantime, EIF3a is involved in the regulation of cell cycle,27 and shows a significant correlation with cell growth 28 and differentiation.29 Recent studies have found that EIF3a is closely related to the occurrence, development, prognosis and chemotherapy efficacy of tumors.17 Moreover, EIF3a gene polymorphism is also associated with the susceptibility of malignant tumors.30 This evidence concerns the gene EIF3A and cancer.