Numerous studies showed that constitutive activation of STAT3 was associated with chemoresistance in human ovarian cancer cells.14, 24, 36, 37, 38 Moreover, a higher level STAT3 activity was reported in 3D vs 2D SKOV‐3 cell culture.39 This raises the question of whether Gal‐3 could mediate chemoresistance through STAT3 activation. Here, STAT3 is linked to ovarian cancer.