LGALS3 and ovarian cancer: Numerous studies showed that constitutive activation of STAT3 was associated with chemoresistance in human ovarian cancer cells.14, 24, 36, 37, 38 Moreover, a higher level STAT3 activity was reported in 3D vs 2D SKOV‐3 cell culture.39 This raises the question of whether Gal‐3 could mediate chemoresistance through STAT3 activation.