KCTD7 and Encephalopathy: For example, until 2012 there was only a single publication implicating KCTD7 mutations in disease.38 Similarly, a separate cohort of patients with encephalopathies attributed to vaccine reactions were instead due to de novo mutations in SCN1A.104, 105 Thus, from a policy perspective as well as from a therapeutic perspective, new knowledge about KCTD family protein functions is urgently needed.