A moderate increase in chitotriosidase activity is also observed in individuals with NPA, NPB, NPC, lysosomal acid lipase deficiency (Wolman disease, CESD), gangliosidosis GM1, and Krabbe disease (Ries et al. 2006; Wajner et al. 2007). The gene discussed is CHIT1; the disease is GM1 gangliosidosis.