To characterize the impact of MYD88 mutations on the transcriptome of CLL cells, we compared gene expression profiles (GEP) of 18 MYD88-mutated CLL cases with 398 cases without mutation in this gene and further restricted this analysis to CLL IGHV-mutated cases (n = 249), as all 18 cases with MYD88 mutations were among this group. The gene discussed is MYD88; the disease is B-cell chronic lymphocytic leukemia.