MYD88 and B-cell chronic lymphocytic leukemia: We further tested the cytotoxic activity of ND2158 for CLL cells that were stimulated with TLR agonists and confirmed significantly lower levels of cell viability in treated versus untreated samples, for both MYD88-mutated and -unmutated cases after 2 and 6 days of incubation (Fig. 3b).