The TLR expression profiles in the three subgroups were very similar, with high expression levels of TLR1, TLR7 and TLR10, and intermediate levels of TLR2, TLR4, TLR6, TLR8 and TLR9. CLL cells expressed low levels of TLR3 and TLR5 (Fig. 1a). This evidence concerns the gene TLR8 and B-cell chronic lymphocytic leukemia.