The highest levels of phosphorylated IκBαpS32/36 and STAT3pY705 were observed in CLL cells after stimulation with Pam3CSK4, HKLM, FSL1 and ODN2006 (TLR1, -2, -6 and -9 agonists) (Supplementary Fig. S2). This evidence concerns the gene TLR1 and B-cell chronic lymphocytic leukemia.