Tumor-specific IGK locus gene rearrangements and their specific clonotypes could be detected in all 14 samples (100%) analyzed by NGS, while IGHV-IGHD-IGHJ and IGHD-IGHJ gene rearrangements were detected in 10 of 14 (71%), and 13 of 14 (93%) B cell lymphoma cases by NGS, respectively. This evidence concerns the gene IGHD and neoplasm.